Ocrelizumab now available for those with primary progressive MS


, the first disease-modifying treatment (DMT) to be proven in slowing down the progression of primary progressive multiple sclerosis (PPMS), has finally been signed off for use at a clinical level.The DMT has been licensed for relapsing-remitting (RR) MS for almost a year, but despite being the first drug to show efficacy in the progressing form of the condition, has not been available to those living with PPMS until now due to the cost associated with the treatment.However, after licensing the drug for RRMS in June 2018, the National Institute for Health and Care Excellence (NICE) committed to further talks with the manufacturers, pharmaceutical company Roche, and they have now brokered a deal acceptable to both parties.Whilst this is a brilliant landmark on the road to effective, optimal treatment for all those living with MS, it is only an early step. At present, there is insufficient evidence to support the use of the drug for all those living with PPMS, and of the 6,000 to 8,000 people with the condition, it is estimated that fewer than 3,000 of them are likely to receive it in the near future. It is also unclear how equitable access to the treatment will be across the UK.The approval criteria for access is currently reliant on all three of the following being met. If the individual:

  • has had symptoms of primary progressive MS for 15 years or less and
  • is able to walk 20 metres or more, with or without walking aids (up to EDSS 6.5) and
  • has evidence of MS activity on MRI scan

Clinical use of Ocrelizumab for PPMS patients will provide increasing data, and the hopes are that evidence will mount in favour of more and more people receiving the treatment.

Related articles

Uniquely practical education, producing specialist clinical leaders transforming local healthcare

Neurology Academy is an innovative educational provider for healthcare professionals including consultants, specialist nurses, pharmacists, therapists and other allied health professionals. Our courses are developed by practicing specialists who combine their experience and expertise into case-based learning designed to create specialists in their field with confidence in effecting change.